ELRIG-Forum 2025: Abstracts
Timur Samatov, Vladimir Galatenko, Evotec SE, Göttingen
Today, Omics data is recognized as having great value for drug discovery. This is driven by the need to make informed decisions and enabled by the technology development in wet lab data generation as well as in in silico tools for data analysis. Transcriptome profiling is an efficient way to get deep insights into the complex biology of cellular model systems. Implementing transcriptomics in a high throughput screening format opens unprecedented opportunities for large-scale quantification of cellular responses to small molecule and ASO treatment, gene manipulation, and other perturbations.
Evotec’s high-throughput transcriptomics platform ScreenSeq™ belongs to the company’s PanOmics industrialized data generation portfolio. It follows the strategy of specific barcoding of individual samples in 384 well plate format followed by pooled sequencing. The workflow has been validated for more than 150 cellular models. It is highly automated, scalable, and quality controlled.
Richard. Rösch, Fraunhofer IPA, Stuttgart
The introduction of mobile robots in laboratories aims to enhance process flexibility, optimize workflows, and relieve staff from repetitive tasks. Current robotic systems are often limited to standardized formats and require integration with other systems. To address these limitations, Fraunhofer IPA is developing a flexible, autonomous mobile laboratory robot that envisions independently taking on tasks. One potential use case involves preparing chemicals for weighing, where the robot would locate chemical cabinets using an internal database, recognize handles, and autonomously open cabinets. It would scan and identify containers, calculate movements to grab target items, and transport them to the weighing station. Preliminary results show promise in the robot's ability to detect and manipulate various objects.
Wladimir Labeikovsky, Ribbon Bio, Vienna
Ribbon Bio is a synthetic biology company that aims to manufacture synthetic DNA molecules of arbitrary complexity at the highest quality. Our technology rests on proprietary algorithms that evaluate each target molecule to arrive at the optimum set of nucleic acid building blocks and the optimum sequence of proprietary enzymatic reactions from our toolbox to assemble error-free DNA. To achieve this on a scale we need to solve two problems: (1) to reliably translate algorithm results into instructions for automated lab equipment and (2) to do so in a way that maximizes the number of molecules we manufacture simultaneously. The interplay of all the elements of our technology (algorithms, biochemistry, automation) enabled by our data infrastructure will be described.
Arne Kusserow, Merck KGaA, Darmstadt
Many aspects of digitalization are discussed for years and years. Many initiatives for standardization were established and failed to set proper “standards”. Meanwhile the demand for better data increased, but the number of adequate solutions did not. We can’t wait until the perfect solution is commercially available, so what can we do, what are the options and how can we start digitalization and automation without being locked into a single solution? We will present a practical approach for lab digitalization an discuss how we approach the challenges, use the opportunities, and what we learned from our exchange with other organization having the same problems.
Martin Neumann, Infoteam Software AG, Bubenreuth
Der Cyber Resilience Act (CRA) stellt einen bedeutenden Schritt der EU zur Stärkung der Cybersicherheit vernetzter Produkte und Software dar. Die Verordnung setzt neue Anforderungen an Sicherheitsmaßnahmen, Schwachstellenmanagement und Transparenz über den gesamten Produktlebenszyklus hinweg. Besonders in der Laborbranche, die zunehmend auf vernetzte Analysegeräte, digitale Laborinformationssysteme (LIMS) und IoT-Technologien angewiesen ist, ergeben sich daraus neue Herausforderungen und Verpflichtungen für Hersteller und Betreiber und auch die Lieferkette. Der Vortrag gibt einen Überblick über die zentralen Inhalte des CRA, zeigt die spezifischen Auswirkungen auf Laborumgebungen auf und diskutiert praxisnahe Ansätze zur Umsetzung der neuen Sicherheitsanforderungen
